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‪‪Zaira Wasim‬, ‪Dangal | ‪Vistara‬ | ‪Mumbai‬‬ | Molestation | Harassment By Passenger

‪‪Zaira Wasim‬, ‪Dangal | ‪Vistara‬ | ‪Mumbai‬‬ | molestation |  harassment


The 17-year-old actress has alleged that a middle-aged man sitting behind her on flight tried to molest her.









Mumbai: Actor Zaira Wasim has alleged she was molested by a co-passenger on board a Delhi-Mumbai flight, prompting the Maharashtra State Commission for Women to seek an inquiry into the "shameful" incident.


Zaira, who had played the young Geeta Phogat in Aamir Khan's blockbuster film Dangal, had last night taken to Instagram to post a story wherein she alleged a middle-aged man tried to molest her when she was en route Mumbai from Delhi by an Air Vistara flight.

ZAIRA Wasim :I felt somebody brushing against my back-Watch

So I was in a flight traveling from Delhi to Mumbai today and right 

behind me one middle-aged man who made my 2 hour journey miserable."

"Guess he couldn't sit like a civilized human being and placed his foot 

on my arm rest while he's fully phelaoed his body on his seat".

"I tried to record it on my phone to understand it better but because

 the cabin lights were dimmed, I failed to get it."

"It was all chill till I felt somebody brushing against my back while 

I was half asleep."

"I ignored it the first time. Blamed the turbulence for it. Until I woke me up to 

this pleasent sight of his beautiful foot rubbing my back and neck."

"Slow claps for Vistara's crew guy! Wonderful!" 

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Malaria is no longer in decline and that should worry us all

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Migraine drug makes people have fewer ‘migraine days’

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अंडा शौकीनों के लिए अच्छी खबर, फायदा पढ़कर चौंक जाएंगे आप

अंडा खाने के शौकीन के लिए अच्छी खबर ये है कि अंडों के भाव में आई तेजी अब थम गई है. अंडों के मौजूदा होलसेल रेट में भारी गिरावट आई है

आपने ये तो सुना ही होगा कि 'संडे हो या मंडे, सर्दी हो या गर्मी रोज खाओ अंडे'. जी हां, अंडा है ही इतना कमाल का कि सभी को इसे अपनी डाइट में शामिल करना चाहिए. अंडा एक सुपर फूड है. इसे खाने से आपको प्रोटीन, कैल्‍शियम और ओमेगा 3 फैटी एसिड मिलता है. जहां प्रोटीन हमारे शरीर की मांसपेशियों को मजबूत बनाता है वहीं कैल्‍शियम से दांतों और हड्डियों को मजबूती मिलती है. खास बात यह है कि अंडे में मौजूद ओमेगा 3 फैटी एसिड शरीर में अच्‍छे कॉलेस्‍ट्रोल यानी कि एचडीएल बनाता है. आपको बता दें कि खाने-पीने की बहुत कम चीजें ऐसी हैं जिनमें ओमेगा 3 फैटी एसिड पाए जाते हैं और अंडा उनमें से एक है

अंडा खाने के शौकीन के लिए अच्छी खबर ये है कि अंडों के भाव में आई तेजी अब थम गई है. अंडों के मौजूदा होलसेल रेट में भारी गिरावट आई है. अभी भी अंडे साढ़े 6 से 7 रुपए तक बेचे जा रहे हैं. हालांकि, पिछले एक हफ्ते में अंडों के होलसेल भाव में गिरावट आई है. अंडे का भाव होलसेल 455 रुपए(प्रति सैंकड़ा) तक आ गया, वहीं कुछ दुकानदार आगे 480-90 रुपए (प्रति सैंकड़ा) तक भी बेच रहे हैं. ऐसे में रिटेल में भी इसकी कीमतों में गिरावट संभव है.

अंडा शाकाहारी है या मांसाहारी? वैज्ञानिकों ने ढूंढ लिया ये जवाब

चौंकाने वाले हैं अंडे के ये 5 फायदे...

1. वजन घटाने और बढ़ाने में मददगार 
अंडा आपके वजन को कंट्रोल करने में काफी मददगार है. दरअसल, अंडा खाने के बाद भूख शांत हो जाती है. इसे खाने के बाद देर तक आपका पेट भरा रहता है और आप ओवरईटिंग से बच जाते हैं. अगर आप अपना वजन कम करना चाहते हैं तो अंडे का सिर्फ सफेद भाग ही खाएं क्‍योंकि पीले वाले हिस्‍से में कॉलेस्‍ट्रोल काफी ज्‍यादा होता है. जो लोग जिम जाते हैं उनकी डाइट में अंडे को विशेष तौर पर शामिल किया जाता है. लेकिन उन्‍हें सिर्फ सफेद हिस्सा ही खाने की सलाह दी जाती है. वहीं, जिन लोगों को वजन बढ़ाना है उन्‍हें अंडे का पीला वाला हिस्‍सा खासतौर पर खाना चाहिए. जिन बच्‍चों का वजन कम होता है उन्‍हें रोजाना एक अंडा खाने की सलाह दी जाती है.

चिकन से भी महंगा हुआ अंडा, जानिए क्या है इसका असली कारण

2. बढ़ाए आंखों की रोशनी
अंडे में भरपूर मात्रा में कैरोटिनायड्स पाया जाता है जो आंखों के सेहत के लिए बेहद जरूरी है. कैरोटिनायड्स आंखों की मांसपेशियों को मजबूती देता है. रोजाना एक अंडा खाने से मोतियाबिंद का खतरा नहीं रहता. इसमें मौजूद एंटीऑक्सीडेंट्स, रेटीना को मजबूती देने का काम करते हैं.

3. बढ़ाए याद्दाश्त, भगाए टेंशन 
अंडे में मौजूद ओमेगा 3, विटामिन और फैटी एसिड दिमाग के लिए बहुत फायदेमंद हैं. यही नहीं अंडे में कोलीन पाया जाता है, जिससे याद्दाश्त तेज होती है और दिमाग एक्टिव रहता है. इसके अलावा अंडे में मौजूद विटामिन B-12 टेंशन को दूर करने में मदद करता है. इसमें कुछ ऐसे तत्व भी पाए जाते हैं जो डिप्रेशन दूर कर मूड अच्‍छा बनाते हैं.

हेल्थ से जुड़ी अन्य खबरें पढ़ने के लिए इस लिंक पर क्लिक करें

4. बालों और त्‍वचा के लिए गुणकारी
अंडे के पीले भाग में बायोटिन होता है जो बालों को मजबूती और त्‍वचा को कसाव देता है. अंडे के पीले भाग को बालों में लगाने से बाल कोमल और मुलायम होते हैं. अंडे की जर्दी को फेसपैक या मास्क की तरह इस्‍तेमाल कर आप त्वचा की झुर्रि‍यों को कम कर सकते हैं.

5. एनर्जी से भरपूर
अंडा खाने से आपके शरीर को भरपूर एनर्जी मिलती है. नाश्‍ते में अंडा खाने से आप दिन भर ऊर्जावान बने रहेंगे. इसके अलावा यह आपकी कार्यक्षमता में इजाफा भी करता है.

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बस 3 महीने आजमाएं ये घरेलू नुस्खे, सबसे लंबे होंगे आपके बाल

हर महिला और लड़की की चाहत होती है घने और लंबे बाल. लेकिन आजकल भागदौड़ और तनाव भरी जिंदगी में यह चाहत अधूरी रह जाती है. कई रिपोर्ट से भी यह सामने आ चुका है कि तनाव के कारण महिलाओं के बाल झड़ने की शिकायत आती है.

हर महिला और लड़की की चाहत होती है घने और लंबे बाल. लेकिन आजकल भागदौड़ और तनाव भरी जिंदगी में यह चाहत अधूरी रह जाती है. कई रिपोर्ट से भी यह सामने आ चुका है कि तनाव के कारण महिलाओं के बाल झड़ने की शिकायत आती है. बाजार में बिकने वाले कई केमिकल युक्त शैंपू भी बालों को नुकसान पहुंचा रहे हैं. आप यदि गौर करें तो कुछ घरेलू उपायों से भी बालों को सुंदर और लंबा बनाया जा सकता है. कुछ घरेलू उपाय बालों को लंबा करने में बेहद कारगर साबित होते हैं. इस लेख के माध्यम से हम आपको बता रहे हैं ऐसे ही कुछ घरेलू उपाय, जिन्हें तीन महीने तक यूज करने पर आपके बाल सबसे लंबे हो 

आलू का रस
यदि आपके बाल झड़ रहे हैं तो आलू का रस बालों के झड़ने की समस्या को कम कर उन्हें घना और लंबा करने में मदद करता है. दो या तीन आलू को पीसकर या जूसर से इनका जूस निकाल लें. अब इस जूस को सिर धोने से 15 मिनट पहले अपने सिर में लगा लें. 15 मिनट बाद सिर को शैंपू से धुल लें. आलू में मौजूद विटामिन बी आपके बालों को मजबूत और लंबा बनाता है.

एलोवेरा पहुंचाए फायदा
एलोवेरा बहुत ही फायदेमंद चीज है. पेट से लेकर चोट और बालों से लेकर चेहरे तक एलोवेरा फायदा पहुंचाता है. ऐलोवेरा जेल महीने में दो बाा्र लगाएं. इसमें आप नारियल का तेल मिला लें तो यह और भी अच्छा होगा. इसके अलावा ऐलोवेरा जूस पीने से भी आपको कई तरह से फायदा होगा.

आंवला
आंखों के साथ आंवला बालों के लिए भी फायदेमंद है. आंवला में विटामिन सी का भंडार है. इसका सेवन बालों के साथ ही आंखों की रोशनी में भी फायदा पहुंचाता है. सिर में प्रयोग करने के लिए आंवला पाउडर और नींबू के रस को बराबर भागों में मिला लें. अब इस मिश्रण को बालों पर लगाना शुरू करें. इसके बाद अपने सिर को गुनगुने पानी से धोकर सूखने दें.

यह भी पढ़ें : अंडा शाकाहारी है या मांसाहारी? वैज्ञानिकों ने ढूंढ लिया ये जवाब

नींबू का रस
दो चम्मच नींबू के रस को थोड़े गुनगुने पानी के साथ मिलाकर बालों में तेल की तरह मालिश कर लें. इसे लगाना के बाद 30 मिनट तक सिर को सूखने दें. इसके बाद गुनगुने पानी और शैंपू से अपने बालों को धो लें. आप इसका प्रयोग सप्ताह में दो बार कर सकते हैं.

प्याज
प्याज का रस सिर को साफ रखने में आपकी मदद करती है. दो प्याज को लेकर इसे छोटे-छोटे टुकड़ों में काट लें. अब इसका रस निचोड़ लें. इसे अपने सिर पर लगा लें. ऐसा 30 मिनट के लिए करें. इसके बाद बाद गुनगुने पानी और शैंपू से अपने बालों को धो लें. इसका प्रयोग करने पर आपको अपने बालों में जल्द बदलाव दिखाई देने लगेगा.

यह भी पढ़ें : टमाटर और खीरे से जुड़ी ये खबर आपको परेशान कर देगी, जानना जरूरी है!

दही और अंडा
अंडे में प्रचुर मात्रा में प्रोटीन पाया जाता है. नियमित रूप से प्रोटीन की मात्रा मिलने से बाल मजबूत होते हैं. एक या दो अंडे लेकर इसके अंदर का पीला व सफेद हिस्सा निकाल लें. अब इसे दो बड़ी चम्मच दही में मिला लें. बालों में लगाकर इसे आधे घंटे के लिए छोड़ दें. इसके बाद इसे गुनगुने पानी और शैंपू से धुल दें. इससे बालों की जड़े मजबूत होंगी और आपके बाल भी लंबे होंगे.

संतरे का रस
संतरे का रस भी बालों को घना और लंबा बनाता है. बालों को लंबा करने के लिए यह एक अच्छा तरीका है. संतरे का रस और सेब का गूदा मिलाकर बालों में लगाने से आपके बाल लंबे और काले होते हैं. इस तरह का मिश्रण एक सप्ताह में दो बार आप अपने बालों में लगा सकते हैं.

हेल्थ से जुड़ी अन्य खबर पढ़ने के लिए यहां क्लिक करें

मेहंदी
मेहंदी का प्रयोग बालों के लिए बहुत ही गुणकारी है. मेहंदी को लोहे की कढ़ाही में भिगोकर एक रात के लिए छोड़ दें. अब इसे अगले दिन अपने सिर में लगाकर सूखने तक छुएं न. पूरी तरह सूखने पर अपने बालों को गुनगुने पानी और शैंपू से धो लें. इस तरह बालों में मेंहदी लगाने से यदि आपका कोई बाल सफेद हैं तो वह अलग से दिखाई नहीं देगा और बालों की चमक भी बढ़ेगी.

जैतून का तेल
तेल मालिश सिर और बाल दोनों के लिए फायदेमंद होती है. जैतून के तेल को हल्का गुनगुना करके अपने बालों और सिर में 45 मिनट तक मालिश करें. हो सकें तो मालिश करने के बाद सिर को एक रात के लिए ऐसे ही रहने दें. अब अपने बालों को शैंपू से धुल लें. इससे आपके बाल स्वस्थ होंगे और इनमें चमक भी बढ़ेगी.
long hairhome remedies for hairhair growthबालों को लंबा करने के नुस्खेtips for long hair

कैसे लड़कियों को पटायें II how to impress girl quickly II SANDEEP MAHESHWARI

कैसे लड़कियों को पटायें II how to impress girl quickly II SANDEEP MAHESHWARI

Sandeep Maheshwari is a name among millions who struggled, failed and surged ahead in search of success, happiness and contentment. Just like any other middle class guy, he too had a bunch of unclear dreams and a blurred vision of his goals in life. All he had was an undying learning attitude to hold on to. Rowing through ups and downs, it was time that taught him the true meaning of his life.

And once discovered, he consistently kept resigning from his comfort zone and to share the secret of his success with the entire world. It is this very urge of helping people and doing something good for the society that inspired him to take the initiative of changing people's lives in the form of "Free Life-Changing Seminars and Sessions".

No wonder people connect with him and his mission of 'Sharing' is now being actively propagated and practiced by millions. It is his diligent focus, the great support of his family and the faith of his team that keeps him going.

for more information
visit-
https://www.sandeepmaheshwari.com/

बचपन का मोटापा सेहत की प्रमुख समस्या

नई दिल्ली
देश में लगभग 1 करोड़ 44 लाख बच्चों का वजन सामान्य से अधिक है। मोटापा कई स्वास्थ्य समस्याओं का प्रमुख कारण है और विश्व स्तर पर लगभग 2 अरब बच्चे और वयस्क इस तरह की समस्याओं से पीड़ित हैं। इस बारे में इंडियन मेडिकल असोसिएशन का कहना है कि आजकल बच्चों में मोटापे की वृद्धि दर वयस्कों की तुलना में बहुत अधिक है। आंकड़ें बताते हैं कि मोटे बच्चों के मामले में चीन के बाद दुनिया में भारत का दूसरा नंबर है। बॉडी मास इंडेक्स BMI को मापकर बचपन में मोटापे की पहचान की जा सकती है। 85 प्रतिशत से 95 प्रतिशत तक BMI वाले बच्चे मोटापे से ग्रस्त माने जाते हैं। ओवरवेट और मोटापे से ग्रस्त बच्चे अपेक्षाकृत कम उम्र में गैर-संचारी रोगों (NSD) जैसे मधुमेह और हृदय संबंधी बीमारियों की चपेट में आ सकते हैं। 

बड़े होकर भी होती हैं समस्याएं
इस बारे में बताते हुए IMA के अध्यक्ष डॉ. के.के. अग्रवाल ने कहा, 'दुनियाभर के बच्चों में मोटापा बढ़ रहा है। भारत भी इससे अछूता नहीं है। बच्चों में अधिक वजन और मोटापे का प्रसार लगातार बढ़ रहा है। अस्वास्थ्यकर भोजन, वसा, चीनी, नमक, जंक फूड और संसाधित भोजन की अधिकता और टीवी, इंटरनेट, कंप्यूटर व मोबाइल गेम्स में अधिक लगे रहने से आउटडोर खेल उपेक्षित हुए हैं। बचपन के मोटापे से ग्रस्त बच्चों में बड़े होकर भी अनेक समस्याएं बनी रहती हैं। बचपन में अधिक वजन और मोटापा अन्य जीवनशैली विकारों जैसे कि टाइप 2 मधुमेह, उच्च रक्तचाप, डिस्लेपिडाइमिया, मेटाबॉलिक सिंड्रोम आदि को जन्म दे सकता है। इसलिए, बच्चों में मोटापे को रोकने और नियंत्रित करने की आवश्यकता है।'

पढ़ें: बच्चे को समय पर सुलाएं और मोटापे से बचाएं

बच्चों में शुरूआत से ही अच्छी आदतें डालें
मोटापे से ग्रस्त बच्चों और किशोरों में स्लीप ऐपनिया जैसे रोग और सामाजिक व मनोवैज्ञानिक समस्याएं अधिक हो सकती हैं, जिससे उन्हें आत्मसम्मान की कमी जैसी समस्याओं से दो चार होना पड़ सकता है। डॉ अग्रवाल कहते हैं, 'बच्चों में शुरूआत से ही अच्छे पोषण संबंधी आदतें पैदा करना महत्वपूर्ण है। सही उम्र से ही पर्याप्त शारीरिक गतिविधि सुनिश्चित करना हर बच्चे के विकास का एक महत्वपूर्ण पहलू है। लाइफस्टाइल रोगों की रोकथाम प्रारंभ करना चाहिए। स्कूल छात्रों के जीवन को आकार देने में मदद कर सकते हैं और बचपन के मोटापे के खिलाफ लड़ाई में महत्वपूर्ण भूमिका निभा सकते हैं। बचपन में स्वस्थ आदतों का मतलब है एक स्वस्थ नागरिक का निर्माण।' 

बच्चों में मोटापा रोकना है तो पिता करें देखभाल

अस्वस्थ आदतों से ऐसे निपटें: 
- शुरूआत में ही स्वस्थ खाने की आदतों को प्रोत्साहित करें।
- कैलरी युक्त खाद्य पदार्थ कम ही दें। 
- अधिक फैट, शुगर और नमक वाले नाश्ते की मात्रा सीमित रखें।
- बच्चों को शारीरिक रूप से सक्रिय होने का महत्व बताएं।
- प्रतिदिन कम से कम 60 मिनट की तेज शारीरिक गतिविधि में बच्चों को भी शरीक करें।
- बच्चों को अधिक समय तक एक स्थान पर बैठने से रोकें।
- बच्चों को बाहर खेलने के लिए प्रोत्साहित करें। 

India in second place in terms of obesity in children

The big truth..... we need to accept that ,

India in second place in terms of obesity in children

About 1.44 million children are overweight in the country. Obesity is a major cause of many health problems and globally, about two billion children and adults suffer from this type of problem.

New Delhi: About 1.44 million children are overweight in the country. Obesity is a major cause of many health problems and globally, approximately two billion children and adults suffer from this type of problem. IMA says that nowadays, obesity growth rate in children is much higher than in adults. Figures show that in the case of obese children, India is second largest in the world after China. Obesity can be identified in childhood by measuring body mass index or BMI.
85% to 95% of children with BMI are considered obese. Overweight and obese children may be vulnerable to non-communicable diseases (NCDs) such as diabetes and cardiovascular diseases at an early age.

Speaking about this, Pachushree Dr K.K., President of Indian Medical Association (IMA) Agarwal said, "Obesity is increasing in children across the world, India is not untouched by it." The increase in weight and obesity in children is increasing continuously. Unhealthy food, fat, sugar and salt (junk food, processed food) Outdoor games have been neglected due to excessive expansions of TVs, internet, computer and mobile games, and many problems continue to grow in children with childhood obesity. Overexposure and obesity can lead to other lifestyle disorders such as type 2 diabetes, hypertension, dyslipidemia, metabolic syndrome etc. Therefore, there is a need to prevent and control obesity in children. "

Our children will die of hunger and those who will be saved from hunger will die by obesity

In obese children and adolescents, diseases such as sleep apnea and social and psychological problems may be more, due to which they may have to face problems like lack of self esteem.

Dr. Agarwal further said, "It is important to create good nutrition habits from the beginning of the children, ensuring adequate physical activity from the right age is an important aspect of the development of every child, should prevent the prevention of lifestyle diseases. Can help shape the life and play an important role in the fight against childhood obesity. Dietary habits mean building a healthy citizen. "

what is this! Obesity is weak from human memory

Handling such unhealthy habits:

In the beginning, encourage healthy eating habits.
Reduce calorie-rich foods. Keep the high-fat and high-sugar or snacks breakfast limited.
Explain the importance of having children physically active.
Involve children in the fast physical activity of at least 60 minutes daily.
Prevent children from sitting in one place for a long time
Encourage children to play outside.

‘Dream Team’ Including La Jollans Gets ‘Stand Up to Cancer’ $7M Grant

The director of the Moores Cancer Center and CEO of the J. Craig Venter Institute — both in La Jolla — will be part of a group that received a four-year, $7 million grant to develop new ways to prevent pancreatic cancer, it was announced Thursday.

Joining colleagues at the MD Anderson Cancer Center in Texas, Johns Hopkins University in Maryland and the Massachusetts Institute of Technology, they’ll form a “dream team” to fight the lethal disease.

Dr. Scott Lippman, the director of the Moores Cancer Center at UC San Diego, accepted the award from Stand Up to Cancer, a division of the Entertainment Industry Foundation, at a conference in Philadelphia.

While his team, including J. Craig Venter, will focus on prevention, another “dream team” formed two years ago is looking into improved treatment. The first group includes Dr. Andrew Lowy and Tannishtha Reya of the Moores Center.

“Because pancreatic cancer occurs deep within the body, it’s hard to detect early,” Lippman said.

“Doctors can’t see or feel tumors during routine physical exams,” Lippman said. “There is no simple blood test for persons without symptoms. By the time symptoms appear, such as weight loss or abdominal discomfort, the disease has likely progressed and metastasized, which of course makes it deadlier.”

Pancreatic cancer is the fourth-leading cause of cancer deaths, even though it’s responsible for just 3 percent of cases, according to the American Cancer Institute. Among those who’ve died of pancreatic cancer in recent years are Apple co-founder Steve Jobs, actors Patrick Swayze and Alan Rickman, and, locally, astronaut Sally Ride and Padres bullpen coach Darrel Akerfelds.

Lippman said the new grant seeks to find ways of fending off disease before treatment is required.

“Before there is cancer, there are often red flags, such as lesions or bits of abnormal tissue,” he said. “Sometimes these lesions don’t change and remain benignly abnormal. They may even regress. But sometimes they transform into cancer.”

— City News Service

‘DREAM TEAM’ INCLUDING LA JOLLANS GETS ‘STAND UP TO CANCER’ $7M GRANT was last modified: October 26th, 2017 by Ken Stone

Dream Team plans to stop pancreatic cancer before symptoms occur

Deeply entrenched and mature by the time it's found, pancreatic cancer is one of the hardest to defeat. A Dream Team assembled by Stand Up to Cancer and led by an investigator at The University of Texas MD Anderson Cancer Center will test new ways to find the disease in its emerging, more vulnerable phase in people who are at high risk for developing it.

"Our plan is to intercept pancreatic cancer by finding it and stopping it before symptoms occur, when the disease is still silent or, even better, before it's actually cancer," said principal investigator Anirban Maitra, M.B.B.S., scientific director of the Sheikh Ahmed Pancreatic Cancer Research Center at MD Anderson.

The team will deploy universal testing for inherited mutations in pancreatic cancer patients, apply deep machine learning to improve imaging, tailor vaccines to knock down emerging disease and sift the best ideas to develop blood tests for predicting risk and detecting precursor or early disease.

Co-leaders of the SU2C-Lustgarten Foundation Pancreatic Cancer Interception Dream Team: Intercepting Pancreatic Cancer in High-Risk Cohorts are Michael Goggins, M.D., professor of pathology, medicine and oncology, Johns Hopkins University, Baltimore; and Scott Lippman, M.D., director of Moores Cancer Center, University of California San Diego Health. Other participating institutions are the Dana-Farber Cancer Institute in Boston, the Massachusetts Institute of Technology and Mayo Clinic.

About 53,670 people will receive a diagnosis of pancreatic cancer in 2017, and about 43,090 will die of the disease, according to the American Cancer Society. Pancreatic cancer accounts for about 3 percent of U.S. cancers but 7 percent of deaths caused by cancer. About 8 percent of patients survive to five years.

The $7 million grant over four years is one of four announced by Stand Up to Cancer in conjunction with various collaborators, including the Lustgarden Foundation for Pancreatic Cancer Research.

Maitra, who also is co-leader of the Pancreatic Cancer Moon Shot™, part of MD Anderson's Moon Shots Program™ to accelerate the development of new approaches based on scientific discoveries to prevent, detect and treat cancer, said there are four projects for the Dream Team.

Using genomic testing to identify those at risk

The overall idea is to take advantage of known risk factors such as germline mutations (inherited abnormalities of DNA) that are known to raise pancreatic cancer risk.

The first step will be to use a sequencing technique from Color Genomics to test the germline DNA of 2,000 consecutive pancreatic cancer patients, in order to identify those with known risk-raising mutations, such as BRCA1 and BRCA2. About 12 percent of all patients carry such mutations.

First-degree relatives of patients who are found to have mutations will then be offered genetic counseling and screening through high-risk clinics, such as the one directed by Florencia McAllister, M.D., assistant professor of Clinical Cancer Prevention through the Pancreatic Cancer Moon Shot at MD Anderson. Those relatives who have mutations will enter an active screening protocol, which includes serial imaging and blood-based biomarker testing.

Machine learning to improve imaging

"If somebody does have silent disease, current CT and MRI scans are woefully inadequate in picking up the small tumors we want to detect," Maitra said. The team will apply computational algorithms to teach computers to recognize pancreatic abnormalities that now escape the human eye, Maitra said.

The goal is to create software packages that could be shared with other institutions. "We're taking standard-of-care imaging but enhancing it with computational algorithms," Maitra said.

Vaccines to intercept disease

Currently cancer-free individuals identified as high-risk due to the presence of germline mutations, who also have pre-cancerous lesions such as cysts on their pancreas, will be enrolled in the first ever vaccine trial to prevent pancreatic cancer.

"Right now, such individuals are followed with endoscopy and periodic imaging, and you hope to catch any progression to cancer early, but there's no active interception to be done for them," Maitra said.

The vaccine, unlike other cancer therapies, is a low-impact treatment that the researchers think is well-suited for interception.

Biomarkers to clarify risk

Molecular biomarkers can be used to identify manifest pancreatic cancer, Maitra said, but "they're awful at detecting occult (silent) disease."

The Dream Team will bring together leaders in the field of biomarker research to test the best biomarker candidates in hundreds of blood samples gathered in a variety of research cohorts that tracked people over time. A fraction of these otherwise healthy people enrolled in longitudinal studies developed pancreatic cancer.

"Something in that person placed him or her at very high risk for pancreatic cancer," Maitra said. Identifying biomarkers in that group can help guide future selection of people who should have more intense screening or early treatment.

Stand Up to Cancer, a division of the Entertainment Industry Foundation, raises funds to accelerate the pace of research to get new therapies to cancer patients quickly by funding teams of top researchers across multiple institutions to collaborate on vital projects.

Source:

https://www.mdanderson.org/newsroom/2017/10/dream-team-aims-intercept-pancreatic-cancer-before-flourishes.html

What do teal pumpkins mean during Halloween?

What does the teal pumpkin mean?

Homes with a teal pumpkin or a teal pumpkin sign out front are letting parents and neighbors know that they are offering non-food treats for trick-or-treaters with food allergies. Use of the symbol is tied to the Teal Pumpkin Project.

What is the Teal Pumpkin Project?

The Teal Pumpkin Project was started by the Food Allergy Community of East Tennessee to raise awareness of food allergies and to encourage families to offer non-food alternatives to candy handouts during Halloween. In addition to handing out candy, participants offered small toys, stickers, and pencils.

The initiative went national in 2014.

Why put out a teal pumpkin?

Many candies are not safe for kids with life-threatening food allergies. For example, consider a child with a peanut or tree nut allergy. Many Halloween candies and snacks are processed in facilities that handle peanuts and nuts, making them off-limits.

The teal pumpkin effort is intended to make Halloween more inclusive, and trick-or-treating a better experience for kids with a range of food allergies.

Why the color teal?

Teal is the official color of food allergy awareness, according to Food Allergy Research & Education, a nonprofit dedicated to food allergy education, awareness, research and advocacy.

It also stands out from traditional Halloween colors like orange and black.

How can I participate?

The first step is to buy a pumpkin, paint it teal and place it outside your home. Stock up on inexpensive toys, like glow-in-the dark bracelets, pencils, erasers and stickers, and start welcoming Halloween trick-or-treaters.

Food Allergy Research & Education, or FARE, offers official Teal Pumpkin Project starter kits with a selection of non-food handouts. It also has a downloadable flyer participants can hand out to parents and grandparents who have questions about the effort.

I don't have time to paint a pumpkin. What are my options?

Teal pumpkins and kits are available for purchase online and at retailers like Target and Walmart. You can also download a free sign from the FARE website and post it on your front door.